Dysregulation in protein production can have profound effects on human health, leading to diseases such as diabetes, heart disease, and cancer. In their search to understand how and why protein synthesis can go awry, scientists are turning to ribosomes, organelles that translate messenger RNA (mRNA) into the nucleotide chains that make up proteins.
Through a technique called ribosomal profiling, scientists gain insight into how protein synthesis is initiated and regulated — with an eye toward developing therapeutic tools to re-stabilize protein synthesis that has gone off-kilter. Ribosomal profiling assesses the location and spatial density of ribosomes on a strand of mRNA, which allows scientists to quantify, among other measurements, the rates at which proteins are synthesized.
Read more here: https://biochem.wisc.edu/2023/07/28/madison-startup-offers-new-tools-for-analyzing-protein-synthesis/